Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study
Long-term GLR supplementation may help preserve cognitive function in individuals at elevated risk for AD, particularly those with MCI. Larger trials are warranted to confirm efficacy and clarify underlying mechanisms.
Authors
- Masahiko Tomiyama (ORCID: https://orcid.org/0000-0001-6660-3160)
- Shuya Kasai (ORCID: https://orcid.org/0000-0001-7171-4885)
- Tomoya Kon (ORCID: https://orcid.org/0000-0001-6072-3954)
- Kazushige Ihara (ORCID: https://orcid.org/0000-0003-3190-0290)
- K. Murashita
- Ken Itoh (ORCID: https://orcid.org/0000-0002-5518-0729)
- Hiroyuki Suganuma (ORCID: https://orcid.org/0000-0001-6596-9881)
- Sunao Shimizu (ORCID: https://orcid.org/0000-0002-8183-4677)
- Shigenori Suzuki
- Chieko Suzuki
- Shigeyuki Nakaji
Institutions
- Hirosaki University (JP)
- Wells Fargo (United States) (US)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fnut.2026.1740494
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- Hirosaki University