Role of ctDNA in predicting the outcome of patients with hormone receptor–positive, HER2-negative advanced breast cancer treated with first-line ribociclib and letrozole: BioItaLEE trial
Pretreatment and early dynamics of ctDNA represent promising prognostic and predictive biomarkers in patients with HR+/HER2- ABC treated with ribociclib/letrozole. Early ctDNA dynamic appeared a promising surrogate biomarker for treatment. Further studies are warranted to validate their clinical utility.
Authors
- G. Allegrini
- Maria Rosaria Valerio (ORCID: https://orcid.org/0000-0003-3589-4684)
- Giulia Bianchi (ORCID: https://orcid.org/0000-0003-3630-4527)
- C. Zamagni (ORCID: https://orcid.org/0000-0002-7143-9091)
- Diletta Valsecchi (ORCID: https://orcid.org/0009-0009-3268-0876)
- Matteo Benelli (ORCID: https://orcid.org/0000-0003-1227-356X)
- Michele Orditura
- Daniela Castelletti
- Nicola Fenderico
- Valentina Guarneri (ORCID: https://orcid.org/0000-0002-2375-8397)
- Maurizio Callari (ORCID: https://orcid.org/0000-0001-5239-0918)
- V. Adamo
- S. Tamberi
- Donatella Grasso
- Lucia Del Mastro (ORCID: https://orcid.org/0000-0002-9546-5841)
- Emanuela Romagnoli
- Luca Malorni (ORCID: https://orcid.org/0000-0002-4297-2997)
- Saverio Cinieri (ORCID: https://orcid.org/0009-0009-1440-7278)
- Ida Paris
- Grazia Arpino
- Alberto Zambelli
- Roberta Caputo
- Filippo Montemurro
- Giampaolo Bianchini
- Marina E. Cazzaniga
- Marco Colleoni
- Michelino De Laurentiis
Institutions
- University of Udine (IT)
- Regione Campania (IT)
- Agostino Gemelli University Polyclinic (IT)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Fondazione Michelangelo (IT)
- Ospedale A. Perrino (IT)
- Ospedale Papa Giovanni XXIII (IT)
- Istituto Oncologico Veneto (IT)
- Presidio Ospedaliero (IT)
- Ospedale per gli Infermi (IT)
- IRCCS Ospedale San Raffaele (IT)
- Novartis (Italy) (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- University of Teacher Education Zug (CH)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- Ospedale di Livorno (IT)
- Candiolo Cancer Institute (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte (IT)
- Hospital of Prato (IT)
- University of Florence (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0650
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00