The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signaling

3-047 combined with ICT reduces neuronal apoptosis and neuroinflammation and improves cognitive dysfunction in diabetic mice, and these effects are potentially associated with downregulation of the TLR4/MyD88/NF-κB pathway.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-26
DOI
https://doi.org/10.3389/fimmu.2026.1704307
Primary Topic
Medicinal Plant Pharmacodynamics Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signaling

D.G. Liu, Yan Xu, Ru Yao, Wenxue Zhao et al.
Frontiers in Immunology
Medicinal Plant Pharmacodynamics Research
article

The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signaling

D.G. Liu, Yan Xu, Ru Yao, Wenxue Zhao, Yuting Wang, Xia Zhuang, Tingmei Mo, Guimin Zhang, Wenjie Ji, Baohua Wang, Jingchun Yao
article en

Abstract

3-047 combined with ICT reduces neuronal apoptosis and neuroinflammation and improves cognitive dysfunction in diabetic mice, and these effects are potentially associated with downregulation of the TLR4/MyD88/NF-κB pathway.

Frontiers in ImmunologyVol. 17
Qingdao University (CN), Shandong University of Traditional Chinese Medicine (CN), Guangdong Pharmaceutical University (CN), Changchun University of Chinese Medicine (CN), Pharmaceutical Formulations (United States) (US), Luye Pharma (China) (CN), The Affiliated Hospital to Changchun University of Chinese Medicine (CN), Ocean University of China (CN)
Good health and well-being
Openalex Percentile: Top 77%
Medicinal Plant Pharmacodynamics Research
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The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signaling — D.G. Liu, Yan Xu, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS