Ex Vivo Organotypic Brain Slice Models for Glioblastoma: A Systematic Review
Organotypic brain slice models represent an extremely relevant tool for translational investigations of GBM biology and treatment response. However, substantial methodological heterogeneity together with limited standardisation hamper reproducibility and cross-study validation. Future work should focus on enhancing reproducibility and harmonising protocols to support the development of clinically meaningful precision oncology strategies.
Authors
- Velia D’Agata (ORCID: https://orcid.org/0000-0003-1114-8265)
- Agata Grazia D’Amico (ORCID: https://orcid.org/0000-0003-4216-417X)
- Giuseppe Broggi
- Cateno C. T. Petralia
- Giuseppe M. V. Barbagallo
Institutions
- University of Catania (IT)
- Policlinico Universitario di Catania (IT)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-25
- DOI
- https://doi.org/10.3390/cancers18030372
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00