Rosuvastatin Reduces Allostatic Overload due to Mechanical Strain: A New Finding on Vascular Remodeling Linked to Hypertension in Spontaneously Hypertensive Rats
Rosuvastatin can reduce vascular remodeling and allostatic overload during hyper-tension by decreasing MS-associated apoptosis/fibrosis in mesenteric VSMC and regulating the NO-Hsp70-WT1 axis, which highlights its potential clinical use in treating hypertension-induced vascular remodeling.
Authors
- Felipe Inserra (ORCID: https://orcid.org/0000-0002-6671-874X)
- Virna Margarita Martín Giménez (ORCID: https://orcid.org/0000-0003-2188-977X)
- León Ferder (ORCID: https://orcid.org/0000-0001-9899-5947)
- Walter Manucha (ORCID: https://orcid.org/0000-0002-2279-7626)
- Alejandro Gutierrez
- Federico García
Institutions
- University of Mendoza (AR)
- University of Crete (GR)
- Universidad Nacional de Cuyo (AR)
- Universidade de Santiago de Compostela (ES)
- Austral University (AR)
- Universidad Maimónides (AR)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Current Hypertension Reviews
- Published
- 2026-01-15
- DOI
- https://doi.org/10.2174/0115734021400864251020044405
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00