Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk
In conclusion, rhein protected the kidneys by activating p-mTOR and downregulating TNF-α, necroptosis and autophagy. Rhein mitigates renal aging and fibrotic injury by targeting TNF-α-mediated autophagy-necroptosis crosstalk, positioning it as a novel multi-target therapeutic agent for age-related kidney injury.
Authors
- Yue Tu (ORCID: https://orcid.org/0000-0002-8560-5986)
- Yigang Wan
- Tianqing Sang (ORCID: https://orcid.org/0000-0002-8851-7797)
- Qijun Fang
- Buhui Liu
- Yinglu Liu
- Liuyunxin Pan
- Wenjie Liu
- Wei Wu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
- Heritage Preservation (US)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fphar.2026.1693000
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing Drum Tower Hospital
- Fundamental Research Funds for the Central Universities