Characterization of pulmonary tuberculosis in high-altitude region using nanopore targeted sequencing
Tuberculosis in Xizang is marked by a high proportion of retreatment cases, low pathogen burden, and a reduced rate of drug resistance-associated gene mutations. Altitude appears to suppress bacterial quantity and may select for specific resistance mechanisms. These findings support the need for targeted TB control strategies in Xizang and underscore the complex interactions among the environment, the pathogen, and the host.
Authors
- Maoshi Li
- Sijuan Ding
- Huan Xu (ORCID: https://orcid.org/0000-0002-6274-908X)
- Anyue Xia
- Shangshi Li
- Shiying Liu
- Xianglong Zeng
- Bin Zhu
- Xiaohui Yu
- Qiu Zhong
- Dongfang Feng
- Jingyu Lin
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- General Hospital of Jinan Military Command (CN)
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- Tibet Autonomous Region People's Hospital (CN)
- IDEX Corporation (United States) (US)
- Second Affiliated Hospital of Zhejiang University (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1186/s12866-026-04761-x
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00