Efficacy and Safety of Biologics, Allergen Immunotherapy, and Pharmacotherapies for Moderate‐to‐Severe Allergic Rhinitis: A Network Meta‐Analysis

This network meta-analysis establishes the first comprehensive treatment hierarchy for moderate-to-severe AR. Our findings demonstrate that biologics, particularly anti-IL-4Rα therapy, are the most effective interventions for nasal symptom control, ranking superior to AIT and pharmacotherapies, thus providing a robust, data-driven framework to personalize patient care.