Therapeutic Potential of Heat Shock Protein 90 Inhibitor 17-DMAG in Regulating METTL3 for Kidney Fibrosis Treatment

N -terminal HSP90 inhibition, along with subsequent c-Jun suppression, contributed to the mechanism underlying 17-DMAG-induced METTL3 downregulation. Through this regulatory pathway, 17-DMAG effectively suppressed METTL3 expression and attenuated kidney fibrosis in both in vitro and in vivo models.

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Publication Details

Journal
Journal of the American Society of Nephrology
Published
2026-01-26
DOI
https://doi.org/10.1681/asn.0000000975
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
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article

Therapeutic Potential of Heat Shock Protein 90 Inhibitor 17-DMAG in Regulating METTL3 for Kidney Fibrosis Treatment

Bada Lee, Jin Woo Choi, Dong Ki Kim, Seung-Pyo Hong et al.
Journal of the American Society of Nephrology
RNA modifications and cancer
article

Therapeutic Potential of Heat Shock Protein 90 Inhibitor 17-DMAG in Regulating METTL3 for Kidney Fibrosis Treatment

Bada Lee, Jin Woo Choi, Dong Ki Kim, Seung-Pyo Hong, Wencheng Jin, Hae Rim Jung, Nayeon Shin, Min Hoan Moon, Jung Pyo Lee, Soo Min Lee, Bogyeong Cho, Seung Hyun Han, Jeonghwan Lee, Da Som Choi
article en

Abstract

N -terminal HSP90 inhibition, along with subsequent c-Jun suppression, contributed to the mechanism underlying 17-DMAG-induced METTL3 downregulation. Through this regulatory pathway, 17-DMAG effectively suppressed METTL3 expression and attenuated kidney fibrosis in both in vitro and in vivo models.

Journal of the American Society of Nephrology
Seoul National University (KR), Seoul National University Hospital (KR), Kyung Hee University (KR), SNUH SMG-SNU Boramae Medical Center (KR)
Good health and well-being
Openalex Percentile: Top 78%
RNA modifications and cancer
DOISourceOpenAlex
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Therapeutic Potential of Heat Shock Protein 90 Inhibitor 17-DMAG in Regulating METTL3 for Kidney Fibrosis Treatment — Bada Lee, Jin Woo Choi, et al. · Journal of the American Society of Nephrology (2026) | TGRS Research Map | TGRS