The role of preoptic area GABAergic neurons in distinctly regulating sleep and rousability under dexmedetomidine sedation in mice

In addition to mediating the sedative versus arousal effects of dexmedetomidine, two distinct subpopulations of GABAergic neurons in the POA are also responsible for promoting natural sleep and wakefulness, respectively.

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Publication Details

Journal
Anesthesiology
Published
2026-01-26
DOI
https://doi.org/10.1097/aln.0000000000005953
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of preoptic area GABAergic neurons in distinctly regulating sleep and rousability under dexmedetomidine sedation in mice

Zhilai Yang, Lei Zhang, Jin Rao, Dijia Wang et al.
Anesthesiology
Sleep and Wakefulness Research
article

The role of preoptic area GABAergic neurons in distinctly regulating sleep and rousability under dexmedetomidine sedation in mice

Zhilai Yang, Lei Zhang, Jin Rao, Dijia Wang, Hu Liu, Qianyun Zhu, Haitao Zhang, Pei Wang, Jin Li, Bin Mei, Yi-Xiang Wang, Beijia Gao, Gaolin Qiu, Wei Dai, Xin Qing
article en

Abstract

In addition to mediating the sedative versus arousal effects of dexmedetomidine, two distinct subpopulations of GABAergic neurons in the POA are also responsible for promoting natural sleep and wakefulness, respectively.

Anesthesiology
Anhui Medical University (CN), First Affiliated Hospital of Anhui Medical University (CN)
Openalex Percentile: Top 79%
Sleep and Wakefulness Research
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