Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament
The differential gene expression among TPPP3+ progenitor-like cells provides a possible target population for studying ligamentous injury and regeneration. Differential expression of collagen and extracellular matrix-related genes provides evidence of specific genes that could be therapeutically targeted to strengthen the ACL and reduce the risk of rupture, particularly in female athletes.
Authors
- Sankalp Sharma
- Steven Garcia (ORCID: https://orcid.org/0000-0002-7833-6677)
- Aboubacar Wague
- Miguel Lizarraga
- Justin Lau (ORCID: https://orcid.org/0000-0002-4904-1853)
- Cristhian F. Montenegro
- Grace D. O’Connell (ORCID: https://orcid.org/0000-0003-0746-1638)
- Stephanie E. Wong (ORCID: https://orcid.org/0000-0003-2204-0444)
- Brian T Feeley
- Kevin C. Wang
- Xuhui Liu
Institutions
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Clinical Pharmacology of Miami (US)
- San Francisco VA Health Care System (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Journal of Bone and Joint Surgery
- Published
- 2026-01-26
- DOI
- https://doi.org/10.2106/jbjs.25.00860
- Citations
- 1
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 39.15