An endovascular porcine model of abdominal aortic aneurysm for interventional radiology research
This study established a fully endovascular, translational porcine model of abdominal aortic aneurysm. The model exhibited a significant mean aneurysmal dilation of about 161% at 4 weeks and 107% at 2 weeks. Serial ultrasound confirmed consistent aneurysm expansion and reproducible growth patterns in surviving animals. Ex vivo analyses demonstrated inflammation and extracellular-matrix damage, mirroring key features of human abdominal aortic aneurysm pathology. This fully catheter-based workflow provides a practical preclinical platform for evaluating imaging techniques and endovascular therapies.
Authors
- Lisa C. Adams (ORCID: https://orcid.org/0000-0001-5836-4542)
- B. Hamm
- Dirk Schnapauff
- Federico Collettini (ORCID: https://orcid.org/0000-0001-5378-461X)
- Julia Brangsch (ORCID: https://orcid.org/0000-0002-5533-8004)
- Jana Möckel (ORCID: https://orcid.org/0000-0002-5365-5604)
- Dilyana B. Mangarova (ORCID: https://orcid.org/0000-0001-5954-3710)
- Jan O. Kaufmann
- Avan Kader (ORCID: https://orcid.org/0000-0002-5453-1267)
- Timo Alexander Auer (ORCID: https://orcid.org/0000-0002-5763-689X)
- Marie-Luise Helene Hildegard Ranner-Hafferl
- Jennifer Mein
- Jennifer Lilly Heyl
- Marcus Richard Makowski
Institutions
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Technical University of Munich (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1186/s41747-025-00673-z
- Citations
- 1
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 36.44
Funders
- Deutsche Forschungsgemeinschaft