Global epidemiology and mortality trends of necrotizing fasciitis: a systematic review and meta-analysis with a focus on monomicrobial Gram-negative infections

The rising proportion and persistently high in-hospital mortality of mono-GNB NF support its recognition as a distinct NF subtype and warrant reconsideration of the conventional NF classifications. In high-prevalence regions, empiric antimicrobial regimens should include prompt Gram-negative coverage to complement surgical debridement, while sustained epidemiological surveillance remains essential.