Evidence-based nursing strategies for the prevention and management of oral mucositis in hematopoietic stem cell transplantation patients

Hematopoietic stem cell transplantation (HSCT) is a cornerstone therapy for hematological malignancies, frequently complicated by treatment-related oral mucositis (OM). This complication leads to severe pain, nutritional compromise, heightened infection risk, and may result in treatment delays, prolonged hospitalization, and diminished long-term health-related quality of life. While clinical guidelines exist, a significant gap persists between evidence and practice, especially in the systematic and individualized application of preventive strategies. From an evidence-based nursing perspective, this perspective article proposes a comprehensive management framework. This framework integrates evidence synthesis, patient-specific risk assessment, dynamic monitoring, and multidisciplinary collaboration to align standardized interventions with personalized patient needs across all phases of HSCT. By synthesizing current evidence, analyzing practical challenges, and proposing a structured management pathway, this perspective article aims to guide clinical practice, inform future research, and ultimately improve care standards for OM in HSCT patients.