Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome

Study findings suggest that accrual of nonresolving chronic inflammation in WML portends development of clinical MS in people with RIS, which may have clinical utility in guiding treatment decisions across the MS spectrum and strengthens the case for including asymptomatic MS in the diagnostic criteria. There is growing recognition that early detection of most chronic neurological diseases is critical to prevent or diminish future disability, and these findings are a specific example of how this principle might operate in practice.

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Publication Details

Journal
JAMA Neurology
Published
2026-01-26
DOI
https://doi.org/10.1001/jamaneurol.2025.5394
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
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article

Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome

Aditya Bharatha, Jorge Correale, Melanie Guenette, Pascal Sati et al.
JAMA Neurology
Multiple Sclerosis Research Studies
article

Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome

Aditya Bharatha, Jorge Correale, Melanie Guenette, Pascal Sati, Elizabeth A. Horwath, Timothy Reynold Lim, Mariano Marrodán, Russell T. Shinohara, Jiwon Oh, Suradech Suthiphosuwan, Daniel S. Reich, Martina Absinta, María Inés Gaitán
article en

Abstract

Study findings suggest that accrual of nonresolving chronic inflammation in WML portends development of clinical MS in people with RIS, which may have clinical utility in guiding treatment decisions across the MS spectrum and strengthens the case for including asymptomatic MS in the diagnostic criteria. There is growing recognition that early detection of most chronic neurological diseases is critical to prevent or diminish future disability, and these findings are a specific example of how this principle might operate in practice.

JAMA NeurologyVol. 83(3)
Cedars-Sinai Medical Center (US), St. Michael's Hospital (CA), National Institutes of Health (US), Humanitas University (IT), Consejo Nacional de Investigaciones Científicas y Técnicas (AR), University of Toronto (CA), Universidad de Buenos Aires (AR), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR), National Institute of Neurological Disorders and Stroke (US), Instituto de Química y Fisicoquímica Biológicas (AR), IRCCS Humanitas Research Hospital (IT), University of Pennsylvania (US)
Openalex Percentile: Top 78%
Multiple Sclerosis Research Studies
DOIOpen Access PDFOpenAlex
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Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome — Aditya Bharatha, Jorge Correale, et al. · JAMA Neurology (2026) | TGRS Research Map | TGRS