Investigating the Mechanisms of <i>Prunella vulgaris</i> against Acute Lymphoblastic Leukemia through Network Pharmacology and Experimental Validation
This study reveals that quercetin, a key active ingredient of <i>P. vulgaris</i>, mediates its anti-ALL activity by modulating the PI3K/AKT/p53 axis while inducing mitochondrial apoptosis. These findings provide reliable experimental evidence for utilizing <i>P. vulgaris</i> in the treatment of ALL.
Authors
- Sutao Zhou
- Chuxuan Li (ORCID: https://orcid.org/0000-0001-9386-9909)
- Bin Zhang (ORCID: https://orcid.org/0009-0006-0660-0375)
- Xia Wang (ORCID: https://orcid.org/0000-0002-4294-8022)
- Xuntao Liu
- Xinran Cao
- Xueqing Xu
Institutions
- Hebei North University (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1021/acsomega.5c09488
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00