Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis

This case represents PG occurring in a patient with ARPC, suggesting that persistent epidermal injury in ARPC may trigger neutrophilic dermatosis. Adalimumab proved effective, offering a safe therapeutic option in PG patients with comorbidities limiting corticosteroid use. Recognition of this association may aid earlier diagnosis and optimize treatment strategies.

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Publication Details

Journal
Case Reports in Dermatology
Published
2026-01-26
DOI
https://doi.org/10.1159/000550460
Primary Topic
Autoimmune and Inflammatory Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis

Kyoko Sugioka, Tomoko Akeda, Akinobu Hayashi, Keiichi Yamanaka et al.
Case Reports in Dermatology
Autoimmune and Inflammatory Disorders
article

Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis

Kyoko Sugioka, Tomoko Akeda, Akinobu Hayashi, Keiichi Yamanaka, Yuki Mizutani
article en

Abstract

This case represents PG occurring in a patient with ARPC, suggesting that persistent epidermal injury in ARPC may trigger neutrophilic dermatosis. Adalimumab proved effective, offering a safe therapeutic option in PG patients with comorbidities limiting corticosteroid use. Recognition of this association may aid earlier diagnosis and optimize treatment strategies.

Case Reports in DermatologyVol. 18(1)
Mie University (JP)
Good health and well-being
Openalex Percentile: Top 78%
Autoimmune and Inflammatory Disorders
DOIOpen Access PDFOpenAlex
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Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis — Kyoko Sugioka, Tomoko Akeda, et al. · Case Reports in Dermatology (2026) | TGRS Research Map | TGRS