A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells

CIr2 induces paraptosis through mitochondrial dysfunction and ER stress, offering a potential therapeutic strategy to overcome apoptosis resistance in TNBC. These findings provide a new mechanistic insight into iridium-based paraptosis induction.

Authors

Wenmin YAO
Jianfen Wei
Houmin Lin
Qinqin Zhang (ORCID: https://orcid.org/0000-0001-9611-435X)
Junfei Jin (ORCID: https://orcid.org/0000-0002-9918-0966)

Institutions

Guilin Medical University (CN)
First Affiliated Hospital of GuangXi Medical University (CN)
Nanxi Mountain Hospital (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2026-01-26
DOI: https://doi.org/10.3389/fphar.2026.1739226
Primary Topic: Cell death mechanisms and regulation
Type: article
Field-Weighted Citation Impact: 0.00

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article

A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells

Wenmin YAO, Jianfen Wei, Houmin Lin, Qinqin Zhang et al.

Jan 26, 2026

Frontiers in Pharmacology

Cell death mechanisms and regulation

article

A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells

Wenmin YAO, Jianfen Wei, Houmin Lin, Qinqin Zhang, Junfei Jin

January 26, 2026article en

Abstract

CIr2 induces paraptosis through mitochondrial dysfunction and ER stress, offering a potential therapeutic strategy to overcome apoptosis resistance in TNBC. These findings provide a new mechanistic insight into iridium-based paraptosis induction.

Frontiers in PharmacologyVol. 17

Guilin Medical University (CN), First Affiliated Hospital of GuangXi Medical University (CN), Nanxi Mountain Hospital (CN)

Good health and well-being

Openalex Percentile: Top 78%

Cell death mechanisms and regulation

DOI Open Access PDF OpenAlex

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