Substratification of mismatch repair deficient endometrial cancers based on mechanism of MMR loss can provide prognostic and predictive refinement
MLH1 loss identifies a subset of MMRd ECs with worse outcomes and lower CD8+ densities supporting substratification of this molecular subtype. Grade, histotype, ER, PR, L1CAM, CTNNB1 and p53 status do not add prognostic refinement within MMRd EC.
Authors
- Spencer D. Martin (ORCID: https://orcid.org/0000-0001-7002-1083)
- Amy Jamieson (ORCID: https://orcid.org/0000-0002-3210-9102)
- Sarah Mah (ORCID: https://orcid.org/0000-0003-1104-7763)
- Allen Zhang (ORCID: https://orcid.org/0000-0001-9455-866X)
- Kathryn McRae
- Derek S. Chiu
- C. Blake Gilks
- David G. Huntsman
- Sila Rogan
- Jessica N. McAlpine
- Stefan Kommoss
Institutions
- Dalhousie University (CA)
- University of British Columbia (CA)
- University Children's Hospital Tübingen (DE)
- McMaster University (CA)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1016/j.ygyno.2026.01.233
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00