Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease

Genomic mutational profiles of FALD and non-Fontan CHS HCCs are distinct from HCCs with other etiologies. Copy number alterations and transcriptional profiles in FALD HCCs classified these into a poor-prognosis group of HCCs.

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Publication Details

Journal
Hepatology
Published
2026-01-26
DOI
https://doi.org/10.1097/hep.0000000000001693
Primary Topic
Congenital Heart Disease Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease

K. Hasegawa, Taizo Mori, Koichiro Haruki, Takehiro Noda et al.
Hepatology
Congenital Heart Disease Studies
article

Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease

K. Hasegawa, Taizo Mori, Koichiro Haruki, Takehiro Noda, Kazuhiro Furukawa, Taiji Yamazoe, Hidetoshi Eguchi, Michitaka Matsuda, Takashi Motomura, 池上 徹, Yuriko Tsutsui, Tatsuya Kanto, Masaaki Mino, Shinichiro Yamada, Shinji Itoh, Takeshi Takamoto, Eiji Kakazu, Tomoharu Yoshizumi, Sachiyo Yoshio
article en

Abstract

Genomic mutational profiles of FALD and non-Fontan CHS HCCs are distinct from HCCs with other etiologies. Copy number alterations and transcriptional profiles in FALD HCCs classified these into a poor-prognosis group of HCCs.

Hepatology
Jikei University School of Medicine (JP), Kyushu University (JP), National Center for Global Health and Medicine (JP), The University of Tokyo (JP), Tokushima University (JP), The University of Osaka (JP)
Good health and well-being
Openalex Percentile: Top 78%
Congenital Heart Disease Studies
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