Dengue vaccination Knowledge, Attitudes, and Practices among healthcare providers in selected countries from Latin America and Asia Pacific

Healthcare professionals (HCPs) perform an essential role in facilitating dengue vaccine uptake, as they are trusted sources of vaccine information and their perspectives shape both patient acceptance and peer adoption. This study assessed HCPs' Knowledge, Attitudes, and Practices (KAP) regarding dengue vaccination, and identified factors influencing their likelihood to recommend the vaccine to patients ('recommendation') and to encourage colleagues to do the same ('advocacy'). A cross-sectional survey of 815 HCPs in Argentina, Brazil, Colombia, Indonesia, Malaysia, and Thailand was conducted. Globally, composite scores were lower for Knowledge (56%) than Attitudes (70%) and Practices (72%). In multivariate analysis, "Perceived ease of recommending dengue vaccines" (recommendation: regression coefficient 0.30, <i>p</i> < .001; advocacy: regression coefficient 0.23, <i>p</i> < .001) and "Urgency to protect against dengue" (recommendation: regression coefficient 0.37, <i>p</i> < .001; advocacy: regression coefficient 0.23, <i>p</i> < .001) were associated with both recommendation and advocacy. In contrast, "Awareness of severity and risk" (regression coefficient 0.24, <i>p</i> = .015) and "Confidence in available dengue vaccines" (regression coefficient 0.34, <i>p</i> < .001) were associated only with recommendation to patients. These findings highlight the need for targeted educational strategies and behavioral interventions to strengthen physician confidence, address barriers to recommending dengue vaccines, and support peer-to-peer advocacy. Such efforts are essential to improving vaccine uptake and maximizing the public health impact of dengue vaccination.