Clonidine Provides Superior Hemodynamic Stability and Analgesia over Midazolam-fentanyl under Monitored Anesthesia Care: Role of Catechol-O-methyltransferase Polymorphism
Clonidine-based MAC provided better intraoperative hemodynamic stability, prolonged analgesia, and reduced postoperative pain compared with midazolam-fentanyl, with minimal respiratory complications. The COMT rs4680 polymorphism did not significantly influence pain perception, highlighting the multifactorial nature of postoperative analgesic response.
Authors
- Ravi Kumar
- Arun Kumar Singh (ORCID: https://orcid.org/0000-0002-2032-2694)
- Rajni Gupta
- Mithilesh Kumar
- Nitu Nigam
Institutions
- Lala Lajpat Rai Memorial Medical College (IN)
- King George's Medical University (IN)
Publication Details
- Journal
- Annals of African Medicine
- Published
- 2026-01-27
- DOI
- https://doi.org/10.4103/aam.aam_677_25
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00