Confined Chiral Pd(II) Catalyst-Enabled Enantioselective Intramolecular Aminoalkylation of Alkenes: One-Step Construction of Chiral <i>N</i> -Fused Bicyclic Skeletons
Highly enantioselective intramolecular aminoalkylation of unactivated alkenes has been accomplished for the first time through the development of a novel category of confined chiral Pd(II) catalysts consisting of two axially chiral picolinic acid ligands. A variety of polycyclic compounds, featuring a saturated chiral <i>N</i>-fused 6/5 or 7/5 bicyclic skeleton, were synthesized in moderate to good yields with excellent enantiomeric ratios (up to 99.5:0.5) through the formation of both a C-N bond and a C-C bond in a single synthetic step.
Authors
- Chuanliang Li (ORCID: https://orcid.org/0000-0003-4831-7130)
- Shouyi Cen (ORCID: https://orcid.org/0000-0002-9786-6067)
- Qi Keng Xu (ORCID: https://orcid.org/0000-0002-9480-4776)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Sijia Ma
Institutions
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1021/jacs.5c18705
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00