Ex Vivo Human Colonic Explants Identify Metabolic Alterations and Cytokine Dysregulation in Ulcerative Colitis: A Pilot Study
UC is characterised by impaired oxidative phosphorylation, enhanced cytokine secretion, and greater glycolytic activity with longer disease duration. These findings support progressive mucosal metabolic alteration as a feature of chronic UC.
Authors
- Jacintha O’Sullivan
- Cathy McShane
- D Kevans
- Fiona O’Connell
Institutions
- Trinity College Dublin (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1007/s10620-025-09665-w
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 30.93