Beyond the Usual: Novel Therapeutic Roles for Established Antidotes

The repurposing of antidotes such as fomepizole, l -carnitine, and naloxone represents a promising frontier in precision toxicology. As the understanding of molecular toxicology deepens, it is becoming increasingly feasible to match antidotes to specific molecular signatures of toxicity, rather than relying solely on syndromic classifications.

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Publication Details

Journal
Therapeutic Drug Monitoring
Published
2026-01-26
DOI
https://doi.org/10.1097/ftd.0000000000001433
Primary Topic
Poisoning and overdose treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Beyond the Usual: Novel Therapeutic Roles for Established Antidotes

Marieke A. Dijkman, Corine C. Visser, Dylan W de lange, Arjen Koppen
Therapeutic Drug Monitoring
Poisoning and overdose treatments
article

Beyond the Usual: Novel Therapeutic Roles for Established Antidotes

Marieke A. Dijkman, Corine C. Visser, Dylan W de lange, Arjen Koppen
article en

Abstract

The repurposing of antidotes such as fomepizole, l -carnitine, and naloxone represents a promising frontier in precision toxicology. As the understanding of molecular toxicology deepens, it is becoming increasingly feasible to match antidotes to specific molecular signatures of toxicity, rather than relying solely on syndromic classifications.

Therapeutic Drug MonitoringVol. 48(2)
Heidelberg University (DE), University Hospital Heidelberg (DE), University Medical Center Utrecht (NL)
Openalex Percentile: Top 80%
Poisoning and overdose treatments
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