Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC

SAHA imposes a common anti-proliferative core but engages distinct lineage-conditioned risk modules in LUAD and LUSC-cell-cycle/migration-linked in LUAD and checkpoint/stress-linked in LUSC. These SAHA feature-sensing modules provide a mechanistic and clinically anchored framework for subtype-tailored HDAC-directed combinations and for future development of HDACi-aligned biomarkers in NSCLC.

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Publication Details

Journal
Clinical Epigenetics
Published
2026-01-27
DOI
https://doi.org/10.1186/s13148-026-02051-x
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC

Yinshan Lin, Xihua Fu, Jianfen Su, Xiaojun Ma et al.
Clinical Epigenetics
Histone Deacetylase Inhibitors Research
article

Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC

Yinshan Lin, Xihua Fu, Jianfen Su, Xiaojun Ma, Qingjun Yang, Guoxing You, Yating Huang, Xi-Yong Yu, Chen Wang, Fei Wang, Lei Shu, Lingmin Zhang, Huiyu Cen, Xiaoling Guan
article en

Abstract

SAHA imposes a common anti-proliferative core but engages distinct lineage-conditioned risk modules in LUAD and LUSC-cell-cycle/migration-linked in LUAD and checkpoint/stress-linked in LUSC. These SAHA feature-sensing modules provide a mechanistic and clinically anchored framework for subtype-tailored HDAC-directed combinations and for future development of HDACi-aligned biomarkers in NSCLC.

Clinical EpigeneticsVol. 18(1)
State Key Laboratory of Respiratory Disease (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 78%
Histone Deacetylase Inhibitors Research
DOIOpen Access PDFOpenAlex
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Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC — Yinshan Lin, Xihua Fu, et al. · Clinical Epigenetics (2026) | TGRS Research Map | TGRS