Umbilical Cord Blood pH Level, Apgar Score, and Attention-Deficit/Hyperactivity Disorder

In this cohort study, an increased odds of ADHD was observed when clinical and biochemical measures of hypoxia were combined as expressed by a low Apgar score and a low umbilical cord pH level at birth. However, when either the Apgar score or the umbilical cord blood pH level was normal, perinatal hypoxia seemed less likely, and no increased odds of ADHD was observed.

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Publication Details

Journal
JAMA Network Open
Published
2026-01-26
DOI
https://doi.org/10.1001/jamanetworkopen.2025.54672
Primary Topic
Neonatal and fetal brain pathology
Type
article
Field-Weighted Citation Impact
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article

Umbilical Cord Blood pH Level, Apgar Score, and Attention-Deficit/Hyperactivity Disorder

Dag Moster, Rolv Terje Lie, Mette Vestergård Pedersen, Morten Søndergaard Lindhard et al.
JAMA Network Open
Neonatal and fetal brain pathology
article

Umbilical Cord Blood pH Level, Apgar Score, and Attention-Deficit/Hyperactivity Disorder

Dag Moster, Rolv Terje Lie, Mette Vestergård Pedersen, Morten Søndergaard Lindhard, Tine Brink Henriksen
article en

Abstract

In this cohort study, an increased odds of ADHD was observed when clinical and biochemical measures of hypoxia were combined as expressed by a low Apgar score and a low umbilical cord pH level at birth. However, when either the Apgar score or the umbilical cord blood pH level was normal, perinatal hypoxia seemed less likely, and no increased odds of ADHD was observed.

JAMA Network OpenVol. 9(1)
Aarhus University (DK), Haukeland University Hospital (NO), Aarhus University Hospital (DK), Regional Hospital Randers (DK), University of Bergen (NO)
Openalex Percentile: Top 78%
Neonatal and fetal brain pathology
DOIOpen Access PDFOpenAlex
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Umbilical Cord Blood pH Level, Apgar Score, and Attention-Deficit/Hyperactivity Disorder — Dag Moster, Rolv Terje Lie, et al. · JAMA Network Open (2026) | TGRS Research Map | TGRS