Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease
This study provides the first evidence that elevated microglial H3K18cr contributes to AD-related cognitive impairment by promoting STAT1 expression and subsequent neuroinflammation. These findings identify microglial histone crotonylation as a novel epigenetic mechanism in AD pathogenesis and suggest that targeting the H3K18cr-STAT1 axis may represent a potential therapeutic strategy for AD.
Authors
- Mengzhu Li
- Ying Weng (ORCID: https://orcid.org/0000-0001-8183-3896)
- Shihong Li
- Maolin Zhong
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-5246-5497)
- Ting He
- Jiazhao Xie
- Xin Wang
- Qiuzhi Zhou
Institutions
- Ministry of Education of the People's Republic of China (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-27
- DOI
- https://doi.org/10.3389/fimmu.2026.1744375
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Sanming Project of Medicine in Shenzhen
- Tongji Medical College, Huazhong University of Science and Technology