α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis
ALA synchronously activates CMA, β-oxidation, and antioxidant responses via a unified AMPK pathway to reduce lipid accumulation and oxidative stress, providing a mechanistically integrated therapeutic strategy for NAFLD.
Authors
- X. Y. Bai
- Jiaojiao Xu (ORCID: https://orcid.org/0000-0001-5436-3059)
- Jianhong Yang (ORCID: https://orcid.org/0000-0003-3939-6471)
- Keting Dong
- Miao Zhang
Institutions
- China Academy of Chinese Medical Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3390/nu18030402
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- University of Chinese Academy of Sciences