Amygdala volume is not associated with MRI-based markers of early cardiovascular disease
PET studies link amygdala activity to cardiovascular disease, while the role of amygdala volume in early cardiovascular disease is unclear. In this large population-based study, 339 asymptomatic adults who underwent comprehensive 3-T MRI with cardiovascular assessment were analyzed. Amygdala volume showed no association with MRI markers of subclinical cardiovascular disease. This is the first large MRI study linking amygdala volume and early cardiovascular disease.
Authors
- Martin Heier
- Franziska Galiè
- Sergio Grosu (ORCID: https://orcid.org/0000-0002-9093-6499)
- Susanne Rospleszcz (ORCID: https://orcid.org/0000-0002-4788-2341)
- Sophia Stoecklein (ORCID: https://orcid.org/0000-0003-0325-4674)
- Ebba Beller (ORCID: https://orcid.org/0000-0002-5268-151X)
- Sarah Schlaeger
- A. M. Peters
- Birgit Betina Ertl-Wagner (ORCID: https://orcid.org/0000-0001-5306-7549)
- Roberto Lorbeer
- Jens Ricke
- Fabian Bamberg (ORCID: https://orcid.org/0000-0002-7460-3942)
- Karl-Heinz Ladwig
- Christopher L. Schlett
Institutions
- University of Freiburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- University Hospital Augsburg (DE)
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- German Centre for Cardiovascular Research (DE)
- SickKids Foundation (CA)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1186/s13244-025-02190-4
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Helmholtz Zentrum München