A plasma proteomic signature of the actin-coagulation axis accurately predicts progression to active tuberculosis
We identified a plasma protein signature that accurately predicts progression from latent to active tuberculosis, linking disease onset to dysregulation of the actin cytoskeleton and coagulation. This biomarker provides a basis for precision preventive therapy and identifies novel host-directed therapeutic targets.
Authors
- Hui Ding (ORCID: https://orcid.org/0000-0002-6875-1172)
- P Lu
- Q Liu
- weiwei Gao
- Xiang Huo
- Jingjing Pan
- Xiaoyan Ding
Institutions
- Nanjing University of Chinese Medicine (CN)
- Ministry of Education (KR)
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Nanjing Second Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fmicb.2025.1746190
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Centers for Disease Control and Prevention