Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques
The supervised clustering of MASLD using a SHAP-converted matrix and UMAP reveals phenotypically distinct subpopulations that improved risk stratification for new onset of CKD. An obese subgroup with atherogenic lipid profiles and hyperuricemia in MASLD is associated with an increased risk for the development of CKD.
Authors
- Nagisa Hanawa (ORCID: https://orcid.org/0009-0000-8702-1645)
- Yukinori Akiyama (ORCID: https://orcid.org/0000-0002-1950-8213)
- Kei Nakata (ORCID: https://orcid.org/0000-0003-0747-7103)
- Hidemichi Kouzu (ORCID: https://orcid.org/0000-0001-7815-1464)
- Tatsuya Sato (ORCID: https://orcid.org/0000-0001-7876-1772)
- Itaru Hosaka (ORCID: https://orcid.org/0000-0002-4005-8229)
- Keitaro Nishizawa (ORCID: https://orcid.org/0000-0002-4520-7887)
- Naoya Yama (ORCID: https://orcid.org/0000-0003-4810-2906)
- Wataru Kawaharata
- Toru Suzuki
- Hiroki Aida (ORCID: https://orcid.org/0009-0007-2615-6010)
- Rie Matsumori
- Koki Abe
- Masato Furuhashi
- Marenao Tanaka
Institutions
- Sapporo Medical University (JP)
- Teine Keijinkai Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1111/hepr.70127
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00