Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials
Spin is common in MS randomized controlled trials with nonsignificant primary outcomes and may mislead clinical decisions. ANN NEUROL 2026;99:316-327.
Authors
- Julia Rey‐Brandariz (ORCID: https://orcid.org/0000-0002-2960-8437)
- Beatriz Casal Acción (ORCID: https://orcid.org/0000-0001-8655-9769)
- Leonor Varela‐Lema (ORCID: https://orcid.org/0000-0001-8365-7961)
- Cristina Candal‐Pedreira (ORCID: https://orcid.org/0000-0002-1703-3592)
- Marta Mascareñas‐García (ORCID: https://orcid.org/0009-0006-8319-8922)
- M. Pérez Ríos
- Guadalupe García
- Carla Guerra‐Tort
- Lucía Martín‐Gisbert
- María Isolina Santiago‐Pérez
- Alejandro Rivero‐de‐Aguilar
Institutions
- Universidade de Santiago de Compostela (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Regional Health (US)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital Montecelo (ES)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1002/ana.78125
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00