Multi-omics identification of immune-related biomarkers predicting tofacitinib response in rheumatoid arthritis
This study provides exploratory integrative multi-omics evidence linking immune-related transcriptomic, proteomic, and metabolic alterations to heterogeneous therapeutic responses in RA. The identified signatures improve our understanding of molecular pathways underlying JAK inhibition response and offer potential candidate biomarkers to guide personalized treatment strategies.
Authors
- Huaxiang Liu (ORCID: https://orcid.org/0000-0001-6989-1428)
- Q D Liu
- Zhen Liu (ORCID: https://orcid.org/0009-0007-9034-2969)
- Fangyi Lu
- Yunfeng Li
- Qilin Chen
- Yanshu Shao
Institutions
- Shandong Provincial Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1703209
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 46.80
Funders
- Shandong University
- Natural Science Foundation of Shandong Province