Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy

This case-control study provides autopsy evidence of a high prevalence of complex spinal pathology in individuals with CTE-NC, supporting the concept of trauma-related encephalomyelopathy. The frequent co-occurrence of p-TDP-43, Aβ, and α-synuclein pathologies in individuals aged 65 years or older with CTE-NC suggests that cumulative trauma might contribute to widespread misfolded protein aggregation.

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Publication Details

Journal
JAMA Neurology
Published
2026-01-26
DOI
https://doi.org/10.1001/jamaneurol.2025.5421
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
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article

Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy

Hidetomo Tanaka, Gábor G. Kovács, Lauren E. Black, David S. Smith et al.
JAMA Neurology
Traumatic Brain Injury Research
article

Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy

Hidetomo Tanaka, Gábor G. Kovács, Lauren E. Black, David S. Smith, Shelley L. Forrest, Krisztina Danics, Nusrat Sadia, Mozhgan Khodadadi, Maria Carmela Tartaglia, William Stewart, Charles Tator
article en

Abstract

This case-control study provides autopsy evidence of a high prevalence of complex spinal pathology in individuals with CTE-NC, supporting the concept of trauma-related encephalomyelopathy. The frequent co-occurrence of p-TDP-43, Aβ, and α-synuclein pathologies in individuals aged 65 years or older with CTE-NC suggests that cumulative trauma might contribute to widespread misfolded protein aggregation.

JAMA NeurologyVol. 83(3)
Semmelweis University (HU), University Health Network (CA), University of Toronto (CA), Toronto Western Hospital (CA), Occupational Cancer Research Centre (CA), Queen Elizabeth University Hospital (GB), Ontario Brain Institute (CA), University of Glasgow (GB), University of Pennsylvania (US)
Openalex Percentile: Top 78%
Traumatic Brain Injury Research
DOIOpen Access PDFOpenAlex
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