Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort

These results indicate that there is no demonstrable difference in arterial stiffness between children with early CKD and those without. Renal function in early CKD does not appear to affect arterial stiffening, independent of the BP. The strong association between arterial stiffening and MAP suggests a need for careful BP control in children with CKD.

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Publication Details

Journal
Pediatric Nephrology
Published
2026-01-26
DOI
https://doi.org/10.1007/s00467-026-07157-1
Primary Topic
Cardiovascular Health and Disease Prevention
Type
article
Field-Weighted Citation Impact
0.00

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article

Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort

Manish Sinha, Mohan T Shenoy, Louise Keehn, Henry Morgan et al.
Pediatric Nephrology
Cardiovascular Health and Disease Prevention
article

Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort

Manish Sinha, Mohan T Shenoy, Louise Keehn, Henry Morgan, Yincent Tse, Pushpa Subramaniam, Andrew Lunn, Rukshana Shroff, Rodney Gilbert, Phil J. Chowienczyk, Jane Tizard
article en

Abstract

These results indicate that there is no demonstrable difference in arterial stiffness between children with early CKD and those without. Renal function in early CKD does not appear to affect arterial stiffening, independent of the BP. The strong association between arterial stiffening and MAP suggests a need for careful BP control in children with CKD.

Pediatric Nephrology
St George's Hospital (GB), Nottingham University Hospitals NHS Trust (GB), University of Liverpool (GB), King's College London (GB), Great Ormond Street Hospital (GB), Royal Hospital for Children (GB), Southampton General Hospital (GB), Bristol Royal Hospital for Children (GB), British Heart Foundation (GB), St George's Hospital (GB), Great North Children's Hospital (GB), Evelina London Children's Healthcare (GB), Alder Hey Children's Hospital (GB), Royal Manchester Children's Hospital (GB), University College London (GB)
King's College Hospital NHS Foundation Trust, National Institute for Health and Care Research, British Heart Foundation, King's College London
Good health and well-being
Openalex Percentile: Top 79%
Cardiovascular Health and Disease Prevention
DOIOpen Access PDFOpenAlex
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Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort — Manish Sinha, Mohan T Shenoy, et al. · Pediatric Nephrology (2026) | TGRS Research Map | TGRS