Kupffer Cell-Derived Interleukin-6 Aggravates Radiation-Induced Liver Disease by Activating Hepatocyte STAT3 to Promote Ccng1 Transcription

Paracrine secretion of IL-6 by Kuppfer cells activates STAT3 in hepatocytes through classical signaling. Activated STAT3 increases <i>Ccng1</i> transcription. CCNG1 protein may promote TP53 degradation. When TP53 is downregulated, hepatocyte apoptosis increases significantly, resulting in atypical RILD.