Genomic characterization and sub-clustering of Escherichia coli clonal complex 38 reveal host associated genetic markers
Our findings refine the phylogenetic structure of E. coli CC38 and identify plasmid markers that may enhance genomic surveillance of zoonotic transmission. These results highlight the importance of a One Health approach to monitor antimicrobial resistance across human, food, and animal reservoirs. Together, these insights support data-driven One Health surveillance and intervention strategies.
Authors
- Lars Christoffersen
- Raphael Niklaus Sieber (ORCID: https://orcid.org/0000-0002-0372-128X)
- Frank C Hansen
- Lillian Marie Søes (ORCID: https://orcid.org/0009-0008-1321-1823)
- Barbara Juliane Holzknecht (ORCID: https://orcid.org/0000-0002-0320-5242)
- Marc Stegger (ORCID: https://orcid.org/0000-0003-0321-1180)
- Lance Bradley Price (ORCID: https://orcid.org/0000-0002-8746-5307)
- Mikala Wang
- Flemming Scheutz (ORCID: https://orcid.org/0000-0002-3931-4846)
- Sam Abraham (ORCID: https://orcid.org/0000-0003-0950-2317)
- Maliha Aziz
- Anette M. Hammerum (ORCID: https://orcid.org/0000-0001-9471-1601)
- Louise Roer (ORCID: https://orcid.org/0000-0001-6892-913X)
- Henrik Hasman
- Dennis B. Holmgaard
- Turid S. Søndergaard
- Rene S. Hendriksen
- James R. Johnson
- Hans L. Nielsen
- Kristian Schønning
- Astrid Rasmussen
- Marc T. K. Nielsen
- Daniel E. Park
- Brian D. Johnston
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- University of Minnesota (US)
- Milken Institute (US)
- Murdoch University (AU)
- George Washington University (US)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Slagelse Hospital (DK)
- Minneapolis VA Health Care System (US)
- Hospital South West Jutland (DK)
- European Society of Clinical Microbiology and Infectious Diseases (CH)
- Lillebaelt Hospital (DK)
- Sygehus Sønderjylland (DK)
- Aalborg University (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1038/s43856-026-01402-2
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- George Washington University
- University of Minnesota
- Aarhus Universitet
- Aarhus Universitetshospital
- European Society of Clinical Microbiology and Infectious Diseases
- Murdoch University
- Aalborg Universitet
- Gentofte Hospital
- Odense Universitetshospital
- Rigshospitalet
- Danmarks Tekniske Universitet
- Aalborg Universitetshospital
- Ministeriet Sundhed Forebyggelse
- Faculty of Health and Medical Sciences, University of Western Australia
- Sygehus Lillebælt
- Milken Institute School of Public Health, George Washington University
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet
- Statens Serum Institut