Acetohydroxyacid Synthase (AHAS) as a Promising and UnderexploredTarget for the Development of New Antifungal Agents
Considering structural insights and experimental data, AHAS inhibitors showed promising profile as broad-spectrum antifungals, with low toxicity to humans and the environment, supporting a One Health approach to control fungal infections across human, animal, and environmental health.
Authors
- Daiane de Jesus Viegas (ORCID: https://orcid.org/0000-0002-4829-6395)
- João Pedro Neves de Mello
- Paula Alvarez Abreu
- Vitor Won-Held Rabelo
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Centro Universitário da Cidade (BR)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2026-01-15
- DOI
- https://doi.org/10.2174/0115680266434047251126045111
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00