Propofol at a Sedative Dose Potently Activates the G1-S Phase Transition to Promote Neural Stem Cell Proliferation via Down-regulated FoxO3ap27Pathway
In summary, this study confirms the FoxO3a-p27 axis as a key pathway mediating propofol's proliferative effects on NSCs at sedative concentrations.
Authors
- Wei Ming (ORCID: https://orcid.org/0000-0002-1229-8786)
- Xuanxian Xu
- Liangtian Lan
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Keyu Chen (ORCID: https://orcid.org/0000-0003-0321-0604)
- Wei Xiong (ORCID: https://orcid.org/0000-0003-3592-9373)
- Shujun Sun
- Xia Feng
- Dihan Lu
- Wen Zhang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Current Stem Cell Research & Therapy
- Published
- 2026-01-15
- DOI
- https://doi.org/10.2174/011574888x440453251208150650
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00