Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols

While current management remains mostly palliative, emerging therapies when guided by standardized assessment tools (including the widely used RTOG scale, which remains the clinical gold standard for skin toxicity grading), alongside CTCAE and RISRAS and individualized treatment planning offer hope for reducing acute and long-term skin damage, especially in re-irradiation cases.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-26
DOI
https://doi.org/10.3389/fonc.2025.1736717
Primary Topic
Effects of Radiation Exposure
Type
article
Field-Weighted Citation Impact
0.00

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article

Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols

Yuan Fang, Xuhong Dang, Jiao Cheng, Xiaoquan Zhang et al.
Frontiers in Oncology
Effects of Radiation Exposure
article

Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols

Yuan Fang, Xuhong Dang, Jiao Cheng, Xiaoquan Zhang, Juancong Dong
article en

Abstract

While current management remains mostly palliative, emerging therapies when guided by standardized assessment tools (including the widely used RTOG scale, which remains the clinical gold standard for skin toxicity grading), alongside CTCAE and RISRAS and individualized treatment planning offer hope for reducing acute and long-term skin damage, especially in re-irradiation cases.

Frontiers in OncologyVol. 15
Changzhi Medical College (CN), National Institute for Radiological Protection (CN)
China National Nuclear Corporation
Openalex Percentile: Top 80%
Effects of Radiation Exposure
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Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols — Yuan Fang, Xuhong Dang, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS