Dual-channel hyperuricemia serodiagnostics and drug evaluation by using polyoxometalate-based hydrogel film

Hyperuricemia is closely related to gout, renal disease and cardiovascular disease, and the development of high-performance tools for serodiagnosis and drug efficacy assessment is of great practical significance. In this study, a dual-channel hydrogel film (CHI-PMo V/VI -UOx) is developed for dual-channel detection of uric acid and showed a good quantification performance and linearity in the physiological uric acid level. Combined with the self-developed Android application and multi-channel strategy, it shows high serodiagnostic accuracy of 96.0% and great potential in drug screening. • Our work developed a new urate-sensitive hydrogel film using redox-active phosphomolybdate as cross-linker. • Our work presents an example of using multichannel probe to improve diagnostic accuracy of hyperuricemia. • Our work presents an example of using multichannel probe for evaluation of drug's performance.