Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism
Overall, this study, for the first time, shows that LA is a novel KLK5 inhibitor, as confirmed by molecular docking and kinetic modelling. Additionally, the results highlight that LA can ameliorate rosacea-like dermatitis through dual inhibition of KLK5 and TLR4/NF-κB signaling, while correcting metabolic disturbances, especially in phenylalanine metabolism.
Authors
- Yueye Xu (ORCID: https://orcid.org/0009-0009-5041-5574)
- Junjie Guo
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-9141-2593)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9167-2077)
- Yao Zhang (ORCID: https://orcid.org/0000-0003-4949-2977)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-2513-633X)
- Jingang Xu (ORCID: https://orcid.org/0009-0005-5908-1663)
- Manyu Chen
- Boya Xu
- Jingyun Xu
- Jinhong Zhao
- Hongming Zhou
Institutions
- Wannan Medical College (CN)
- Anhui Provincial Hospital (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1734997
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00