Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway
This study provides compelling evidence for the regulatory role of QCHS on the microbiota-metabolome axis and ferroptosis in UC. It also uncovers a novel function of L. gasseri as a ferroptosis inhibitor, offering promising insights into microbiota-targeted and ferroptosis-modulating therapeutic strategies for UC.
Authors
- Weiyang Li (ORCID: https://orcid.org/0000-0003-1863-1049)
- Lilin Ge (ORCID: https://orcid.org/0000-0001-8129-8926)
- Yuguang Wu
- Wan Feng (ORCID: https://orcid.org/0000-0002-6538-6931)
- zhe Di
- Yuan Cui
- Jingyi Hu
- Ryan Au
- Bin Li
- Yao Lin
- Lei Zhu
- Hong Shen
- Yongchang Miao
- Feng Xu
- Cheng Cheng
- Yanan Li
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Academy of Chinese Culture and Health Sciences (US)
- Lianyungang Oriental Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1186/s13020-025-01317-5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00