Two Streptococcus agalactiae ST283 invasive infections in Portugal raise the possibility of the emergence of this unusual lineage in Europe

The importance of invasive <i>Streptococcus agalactiae</i> (Lancefield group B streptococci - GBS) disease among adults is increasingly recognized worldwide. Acquisition from other humans or an individual's own microbiota is thought to be the origin of the diverse GBS lineages causing these infections. We report two cases in three consecutive years (2016-2018) of invasive GBS disease in Portugal due to the unusual ST283 lineage, a hypervirulent clone circulating in Southeast Asia (SEA) and associated to foodborne transmission and large disease outbreaks among previously healthy younger adults. The need for genetic analyses, which are infrequently performed, to identify ST283 may mean that cases of ST283 occur sporadically outside SEA but go undetected.

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Journal
Frontiers in Microbiology
Published
2026-01-26
DOI
https://doi.org/10.3389/fmicb.2025.1712362
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
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article

Two Streptococcus agalactiae ST283 invasive infections in Portugal raise the possibility of the emergence of this unusual lineage in Europe

Henrique Oliveira, Carla Ferreira, Helena Piúma Gonçalves, Bruno Miguel et al.
Frontiers in Microbiology
Neonatal and Maternal Infections
article

Two Streptococcus agalactiae ST283 invasive infections in Portugal raise the possibility of the emergence of this unusual lineage in Europe

Henrique Oliveira, Carla Ferreira, Helena Piúma Gonçalves, Bruno Miguel, Ana Rita Jesus, Maria Luísa Gonçalves, Hugo Cruz, Adriana Pedrosa, José Miguel Ribeiro, Isabel Campante Cardoso Vale, Gina Marrão, José Mota Freitas, Inês Roxo, Maria Favila Menezes, Elisabete Martins, Rui M. Ferreira, Isaura Terra, Teresa Afonso, Miguel Seruca, Ilse Barros Fontes, Luisa Monleón Sancho, Isabel García Monge, Filomena Martins, Rita Emanuela Fernandes Gralha, José Melo‐Cristino, Elisabete Cristovam, Elzara Aliyeva, Angelina Lameirão, Raquel Sola Díaz, Nuno Canhoto, Marta Vanrell Nicolau, Helena Ramos, Catarina Chaves, Luís Lito, Luísa Boaventura, Maria Fatima Silva, Alexandra Estrada, Teresa Vaz, Gina Marrão, Ezequiel Moreira, Inês Tapadinhas, Marisol Lourinha, Elsa Cristina Moreira Calado, Mykyta Forofontov, Svetlana Zhelezovskaya, Luísa Nunes Galvão Caron de Oliveira, Mário Ramirez, Teresa Morais, Ana Bruschy Fonseca, Hugo Loureiro, Paula Gama, Filipa Fortunato, Sara F. Sampaio, Marília Gião, Vasco Mendes, Andreia Bernardo, José Germano de Sousa, Teresa Pina, Cristina Toscano, Sandra Vieira, Maria Ana Pessanha, Margarida Pinto, Filipa Bazenga, Cristina Marcelo, Margarida Rodrigues, Ana Paula Mota Vieira, Maria Lucas, Maria Calle, Teresa Reis, Adília Vicente, Manuela Azevedo, Fátima Vale, Dr. João Faria, Ana Aguiar, Filipa Vicente, Leonardo Carneiro, Fernando Pereira da Fonseca, Carla Leite, Celeste Pontes, Rui Semedo, Maria Amélia Afonso, Jesuína Duarte, Hermínia Costa, Aurélia Selaru, Joana Ramos, Patrícia Amantegui, Vitória Rodrigues, Hugo Macedo, Sofia Marques, Susana Banza, Cristina Bragança, Ana Custódio, Alberta Faustino, Mariana Fardilha, Paulo Lopes, Natália Novais, Patrícia Pereira, Mariana Bettencourt Viana, Isabel Lourenço, Margarida Pereira, Marvin Oliveira, Ana Helena Correia, L. Nogueira Martins, Isabel Peres, Manuela Ribeiro, Joana Bernardo, Nádia Martins, João Marques, Cláudia Ferreira, Maria Cármen Iglesias, José Diogo, Paula Gouveia Pestana, Luís Fialho, Clara Portugal, Cristina Mota Preto, Maria João Tomás, Valquíria Alves, Isabel Nascimento, José Marta, Elmano Ramalheira, Odete Chantre, Gabriela Abreu, Mariana Silva, Sónia Ferreira, Virginia Lopes, Cláudia Fidalgo, Joana Selada, Isabel Brito
article en

Abstract

The importance of invasive <i>Streptococcus agalactiae</i> (Lancefield group B streptococci - GBS) disease among adults is increasingly recognized worldwide. Acquisition from other humans or an individual's own microbiota is thought to be the origin of the diverse GBS lineages causing these infections. We report two cases in three consecutive years (2016-2018) of invasive GBS disease in Portugal due to the unusual ST283 lineage, a hypervirulent clone circulating in Southeast Asia (SEA) and associated to foodborne transmission and large disease outbreaks among previously healthy younger adults. The need for genetic analyses, which are infrequently performed, to identify ST283 may mean that cases of ST283 occur sporadically outside SEA but go undetected.

Frontiers in MicrobiologyVol. 16
University of Lisbon (PT), Administração Regional de Saúde de Lisboa e Vale do Tejo (PT), Institute for Molecular Medicine (US)
Fundação para a Ciência e a Tecnologia
Life below water
Openalex Percentile: Top 79%
Neonatal and Maternal Infections
DOIOpen Access PDFOpenAlex
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