Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson’s disease mice brain

Collectively, these findings highlight the neuroprotective potential of the Os_9aa, which counteracts α-synuclein- and MPTP-induced neurotoxicity by reducing oxidative stress, glial activation, and neuroinflammation. This multifaceted protection preserves neuronal integrity in both the NSE-hαSyn transgenic and MPTP-induced PD mouse models, underscoring Os_9aa as a promising therapeutic candidate for modifying PD pathogenesis.