Integrated proteomic and transcriptomic profiles reveals the role of OAS3 in dermatomyositis pathogenesis
OAS3 expression was consistently elevated in both plasma and skeletal muscle tissues of individuals with DM. This molecule may act as a key enhancer of type I IFN-mediated pathogenic responses. Our results support the potential of OAS3 as a novel biomarker and therapeutic target in DM.
Authors
- Hongjun Hao
- Yun Yuan
- Feng Gao
- Zhuangzhuang Zhang
- Chenyu Zhuang
Institutions
- Peking University (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1735236
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China