Mechanism Of Keap1-Nrf2-HO-1/GPX4 Signal In Blocking Epileptic Hippocampal Neuron Ferroptosis And Intervention Effect Of Caogouzhimu Decoction

Caogouzhimu decoction exerts anti-epileptic effects, likely by inhibiting hippocampal neuronal ferroptosis through modulation of the Keap1-Nrf2-HO-1/GPX4 signaling pathway. These findings provide a novel perspective for the clinical treatment of epilepsy.

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Publication Details

Journal
Pakistan Journal of Pharmaceutical Sciences
Published
2026-01-22
DOI
https://doi.org/10.36721/pjps.2026.39.3.reg.14944.1
Primary Topic
Ferroptosis and cancer prognosis
Type
article
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article

Mechanism Of Keap1-Nrf2-HO-1/GPX4 Signal In Blocking Epileptic Hippocampal Neuron Ferroptosis And Intervention Effect Of Caogouzhimu Decoction

Dandan Zhang, Zhimin Yu, Jun Zhang
Pakistan Journal of Pharmaceutical Sciences
Ferroptosis and cancer prognosis
article

Mechanism Of Keap1-Nrf2-HO-1/GPX4 Signal In Blocking Epileptic Hippocampal Neuron Ferroptosis And Intervention Effect Of Caogouzhimu Decoction

Dandan Zhang, Zhimin Yu, Jun Zhang
article en

Abstract

Caogouzhimu decoction exerts anti-epileptic effects, likely by inhibiting hippocampal neuronal ferroptosis through modulation of the Keap1-Nrf2-HO-1/GPX4 signaling pathway. These findings provide a novel perspective for the clinical treatment of epilepsy.

Pakistan Journal of Pharmaceutical SciencesVol. 39(3)
First People’s Hospital of Jingmen (CN)
Good health and well-being
Openalex Percentile: Top 79%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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Mechanism Of Keap1-Nrf2-HO-1/GPX4 Signal In Blocking Epileptic Hippocampal Neuron Ferroptosis And Intervention Effect Of Caogouzhimu Decoction — Dandan Zhang, Zhimin Yu, et al. · Pakistan Journal of Pharmaceutical Sciences (2026) | TGRS Research Map | TGRS