Substitution matters: Comparison of four N,1,4-tri(methoxy-2-hydroxybenzyl)-DAZA ligands as potential PET/CT liver imaging agents
Four regioisomers of [<sup>68</sup>Ga]Ga-TMoS-DAZA, a PET/CT radio tracer for liver function imaging, were studied as candidates of potentially improved hepatobiliary biokinetics. Liver uptake and biliary clearance behavior were compared using an in ovo model based on ostrich eggs for PET/CT imaging and ex vivo biodistribution analysis. The tracer lipophilicity was evaluated via logD determination. The experiments showed remarkable differences between the four tracers concerning their maximum liver uptake, percentage of tracer cleared via the biliary tract and their respective logD values.
Authors
- Steffen Wiegand
- Julia Greiser (ORCID: https://orcid.org/0000-0002-3779-6298)
- Wolfgang Weigand (ORCID: https://orcid.org/0000-0001-5177-1006)
- Thomas Winkens (ORCID: https://orcid.org/0000-0002-8958-4801)
- Marta Pomraenke
- Friederike Hüttner
- Martin Freesmeyer
- Birgit Weber
- Anne Zenner
Institutions
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1016/j.nucmedbio.2026.109604
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00