Synthesis and Biological Evaluation of Rigid Benztropine Analogueswith Potential DAT Inhibition Activity: A Prospect in Parkinson’sDisease Treatment
The rigid aromatic sections in fluorenatropine analogs grant a superior activity over DAT, allowing motor symptom mitigation at lower concentrations.
Authors
- César R. Solorio‐Alvarado (ORCID: https://orcid.org/0000-0001-6082-988X)
- Edson Daniel Hernández-Velázquez
- Rafael Ortiz-Alvarado
- Clara Alba-Betancourt
- Luis A. Segura-Quezada
- Luis Chacón-García
- Deisy Gasca-Martínez
- Adán Hernández-Cortés
Institutions
- Universidad de Guanajuato (MX)
- Autonomous University of Queretaro (MX)
- Universidad Michoacana de San Nicolás de Hidalgo (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-15
- DOI
- https://doi.org/10.2174/0109298673405492251015050308
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00